Project Title: Proof of concept; an open label pilot study to determine the efficacy and tolerability of a treated gliadincontaining product in asymptomatic subjects with coeliac disease.

Principle investigators:Dr R. Grant, Prof B. Jones, Dr J. Ashton.

Coeliac disease is an inflammatory disorder affecting the upper small intestine and is usually caused by an allergic response to ingestion of gluten found in wheat, rye and barley causing inflammation of the small intestine often preventing efficient absorption of important nutrients from food. This study is in the process of testing whether a new process for removing toxic gluten proteins is affective. If successful, the treatment process should enable patients with coeliac disease to again eat wheat containing products provided they have been detoxified in this way.

Project title: Proof of Concept, open-label pilot stduy to determine the efficacy and safety of the use of Pedy Phar ointment in the treatment of diabetic foot ulcers.

Sponsor: Pharco
Principle investigators: Dr Ross Grant

Foot ulcerations and infections are a major cause of morbidity in diabetic patients and are a main risk factor for non-traumatic lower-extremity amputation. This study is in the process of testing whether a new ointment is effective and safe for the local treatment of diabetic foot infections.