Enhancing cell viability after UV exposure: the effects of antioxidants, flavonoids and PARP inhibitors.
Exposure to ultraviolet radiation (UVR) is associated with skin aging, skin diseases and the development of various skin cancers, including melanoma. It is capable of directly and indirectly damaging many important cellular macromolecules, including DNA, proteins and lipids.
Much of this damage is associated with free radicals; upon exposure to UVR free radical activity within the cell is enhanced. When this activity outweighs the cell’s natural defenses and repair capacity, the cell sustains damage and is said to be in a state of oxidative stress.
This study will investigate the effects of antioxidants and other treatment types upon cell viability after UVR exposure in an attempt to identify the most effective approach to maintain cellular health and viability in situations of oxidative stress.